A bioactive isoprenylated xanthone and other constituents of Garciniaedulis

Phytochemical investigation on the root bark of Garcinia edulis (Clusiaceae) gave a new isoprenylated xanthone, 1,4,6-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl)-5-(1,1-dimethyl-prop-2-enyl)xanthone (1), a known xanthone, forbexanthone (2) together with three known pentacyclic triterpenoids, friedelin, lupeol and lupeol acetate. The structure of the new compound was fully characterised by NMR spectroscopic analysis. Compound 1 showed significant anti-HIV-1 protease activity with IC50 value of 11.3 µg/mL. Furthermore, compound 1 showed potent cytotoxic activity with LC50 value of 2.36 µg/mL against brine shrimp larva in vitro.

Graphical abstractA novel and bioactive isoprenylated xanthone, garceduxanthone (1) was isolated from the root bark of Garcinia edulis (Clusiaceae) together with other four known compounds. Its structure was fully established by using NMR techniques. Furthermore, compound 1 showed significant anti-HIV-1 protease and cytotoxic activities.Figure optionsDownload full-size imageDownload as PowerPoint slide