Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2539045 | Fitoterapia | 2010 | 4 Pages |
Abstract
Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC50 of 2.92 μM, 1.08 μM and 2.45 μM, respectively.
Graphical abstractA rare new chiratane type triterpenoid, chiratone, with cytotoxic activity was isolated from the rhizomes of Drynaria fortunei.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Yong-hong Liang, Wei Wang, Si-wang Yu, Min Ye, Xiang-hui He, Ning-bo Gong, Yang Lu, Ikhlas A. Khan, De-an Guo,