Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2539068 | Fitoterapia | 2010 | 8 Pages |
The polysaccharide (PAP) from Potentilla anserina was evaluated for modulating effects by using mouse peritoneal macrophage and the immunosuppressed-model cyclophosphamide-induced. Phagocytotic and mononuclear phagocytic system function assays showed that PAP stimulated the phagocytosis of phagocyte. Splenocyte proliferation assay showed that PAP acted the effect combining Con A or LPS in splenocyte proliferation. The parameters detected showed that PAP increased thymus and spleen indices, the levels of LDH and ACP in the spleen, and IL-10and IFN-γ in serum in immunosuppressed mice. The results suggest that PAP is involved in immunomodulatory effects leading to the exploration for PAP as a potential immunostimulant.
Graphical abstractThe polysaccharide from Potentilla anserina showed synergistic stimulation effect in immunosuppressed mice is involved in immunomodulatory effects leading to the exploration for the polysaccharide as a potential immunostimulant.Figure optionsDownload full-size imageDownload as PowerPoint slide