Chemical composition of the green alga Codium Divaricatum Holmes

A new sterol, 24-R-stigmasta-4,25-diene-3β,6β-diol (1), along with three known compounds (2–3), was isolated from the green alga Codium divaricatum Holmes, a traditional Chinese medicine, which is efficacious against cancer. All structures were determined by spectroscopic methods and comparison with related known compounds. Single-crystal X-ray crystallography allowed us to confirm the structure of 1. To our knowledge, the compound 1 is reported as the first from natural source, and compounds 2, 4 have not been isolated from green algae before.

Graphical abstractA new sterol 24-R-stigmasta-4, 25-diene-3β, 6β-diol (1), along with a sterol glycoside 24-R-3-O-β-d-glucopyranosyl-stigmasta-5, 25-diene (2), clerosterol (3), and loliolide (4) was isolated from the green alga Codium divaricatum Holmes.Figure optionsDownload full-size imageDownload as PowerPoint slide