| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2539105 | Fitoterapia | 2011 | 7 Pages |
The Swertia japonica is used clinically as a remedy for gastrointestinal symptoms in Japan. We examined the effects of a S. japonica and swertiamarin on gastric emptying and gastrointestinal motility in atropine-, dopamine-, and 5-hydroxytryptamine (5-HT)-treated mice. All three preparations inhibited reductions in gastric emptying and gastrointestinal motility induced by dopamine (1 mg/kg, intraperitoneal injection, ip). Neither the powder, swertiamarin, nor itopride had any effect on the reductions in gastric emptying and gastrointestinal motility caused by 5-HT (4 mg/kg, ip). These findings suggest that the powder and swertiamarin stimulate gastric emptying and gastrointestinal motility by inhibiting the dopamine D2 receptor.
Graphical abstractThese findings suggest that the powder of Swertaia japonica herb and swertiamarin stimulate gastric emptying and gastrointestinal motility by inhibiting the dopamine D2 receptor.Figure optionsDownload full-size imageDownload as PowerPoint slide
