| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2539118 | Fitoterapia | 2011 | 7 Pages |
Abstract
Quercetin's protective effects on the glomerulosclerosis of diabetic nephropathy (DN) in rat mesangial cells were investigated. The cell cycles, type IV collagen and laminin, TGF-β1 mRNA, Smad 2/3 and Smad 7, and activities of cell antioxidases were measured. Compared with the high glucose group, quercetin may decrease the cell percentages of G0/G1 phase, Smad 2/3 expression, laminin and type IV collagen, and TGF-β1 mRNA level significantly. The antioxidant capacity, the cell percentages of S phase and Smad 7 expression was significantly increased by quercetin. These results suggest that quercetin is a protective agent against glomerulosclerosis in DN.
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Authors
Dao-quan Tang, Ya-qin Wei, Xiao-xing Yin, Qian Lu, Hui-hui Hao, Yun-peng Zhai, Jian-yun Wang, Jin Ren,