Reactive oxygen species scavenging activities and inhibition on DNA oxidative damage of dimeric compounds from the oxidation of (−)-epigallocatechin-3-O-gallate

The dimeric catechins dehydrotheasinensin A (2) and theacitrin C (3) were prepared from the oxidation of (−)-epigallocatechin-3-O-gallate (EGCG, 1), and their antioxidant activity was investigated using a chemiluminescence (CL) method in vitro. Both compounds showed significant inhibitory effects on reactive oxygen species (O2−, H2O2 and •OH) and DNA oxidative damage, with 2 being more potent than 3 and EGCG itself.

Graphical abstractTwo dimeric compounds from the oxidation of (−)-EGCG were prepared and identified. They both showed more potent inhibitory effects on reactive oxygen species and DNA oxidative damage than EGCG itself.Figure optionsDownload full-size imageDownload as PowerPoint slide