Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins

A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids.

Graphical abstractDifferences in the terpenoid moiety of seven phytocannabinoids seem to be far more important for topical anti-inflammatory activity than those at the C-3 alkyl residue.Figure optionsDownload full-size imageDownload as PowerPoint slide