Cerebroside and ceramide from the pollen of Brassica napus L.

The new cerebroside 1-O-(β-d-glucopyranosyl)-(2 S, 3 S, 4R, 8E)-2-[(2′R)-2′-hydroxytetracosenoilamino]-8-octadecene-1,3,4-triol (1) and ceramide (2 S, 3 S, 4R, 8E)-2-[(2′R)-2′-hydroxytetracosenoilamino]-8-octadecene-1,3,4-triol (2) were isolated from the ethyl acetate extract of the pollen of Brassica napus L. The structures of 1 and 2 were elucidated on the basis of chemical and spectroscopic method. Two new compounds were evaluated for activity in vitro assays for the cytotoxic activities against human tongue squamous carcinoma cell line (Tca8113).

Graphical abstractThe new cerebroside (1) and ceramide (2) were isolated from the pollen of Brassica napus L. Compound 2 was shown to possess significant cytotoxic activity against Tca8113 cells.Figure optionsDownload full-size imageDownload as PowerPoint slide