Aporphine alkaloids, clerodane diterpenes, and other constituents from Tinospora cordifolia

Phytochemical investigation of the methanol extract of Tinospora cordifolia aerial parts led to the isolation of four new and seven known compounds. The structures of two new aporphine alkaloids, N-formylasimilobine 2-O-β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranoside (tinoscorside A, 1) and N-acetylasimilobine 2-O-β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranoside (tinoscorside B, 2), a new clerodane diterpene, tinoscorside C (3), and a new phenylpropanoid, sinapyl 4-O-β-d-apiofuranosyl-(1 → 6)-O-β-d-glucopyranoside (tinoscorside D, 6) were determined by extensive spectroscopic methods including FTICR-MS and 1D and 2D NMR.

Graphical abstractTwo new aporphine alkaloids (1, 2), a new clerodane diterpene (3), a new phenylpropanoid (6), and seven known compounds were isolated and identified from the aerial parts of Tinospora cordifolia.Figure optionsDownload full-size imageDownload as PowerPoint slide