| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2539229 | Fitoterapia | 2010 | 8 Pages |
A weak estrogenicity of puerarin on reproductive organs was addressed in female rats. In short-term treatment, immature ovariectomized rats were injected with 0.7 mg/kg BW/day of puerarin, for 14 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the percent of cornified cells (%Co), but it increased the number of uterine glands. In long-term treatment, mature rats were injected with 7.0 mg/kg BW/day of puerarin for 140 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the number of uterine glands, but a significant increase in the %Co was observed from day 98 onwards.
Graphical abstractSubcutaneous injection of puerarin for 140 days in mature female rats exhibited a significant increase in the percent of cornified cells from day 98 onwards, compared to the DW group.Figure optionsDownload full-size imageDownload as PowerPoint slide
