Two new prenylated xanthones and a new prenylated tetrahydroxanthone from the pericarp of Garcinia mangostana

Two new prenylated xanthones and a new prenylated tetrahydroxanthone, garcimangosxanthone A–C (1–3), along with fourteen known xanthones were isolated from the pericarp of Garcinia mangostana. Their structures were elucidated on the basis of spectroscopic data. Compounds 1 and 2 exhibited in vitro cytotoxicity against A549, LAC and A375 cell lines with IC50 values of 5.7–24.9 μM, which were comparable to those of doxorubicin.

Graphical abstractTwo new prenylated xanthones, and a new prenylated tetrahydroxanthone, garcimangosxanthone A–C (1–3) were isolated from the pericarp of Garcinia mangostana. Compounds 1 and 2 exhibited potent cytotoxicity against three tumor cell lines in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide