| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2539293 | Fitoterapia | 2011 | 4 Pages |
The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (−)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were pretreated orally with BISA, and the pain-related behavioral responses to intraperitoneal cyclophosphamide or to intracolonic mustard oil were analyzed. BISA showed a dose-unrelated significant antinociception. Collectively, the results suggest that BISA may be an topical antiinflammatory and visceral antinociceptive agent.
Graphical Abstract(−)-α-Bisabolol is effective topical antiinflammatory agent in the experimental models of acute dermatitis and inhibits visceral nociception induced by cyclophosphamide and mustard oilFigure optionsDownload full-size imageDownload as PowerPoint slide
