Isolation and identification of degradation products of salvianolic acid A by NMR and LC-MS

Salvianolic acid A was subjected to thermal degradation condition in distilled water at 90 °C. Four degradation products, including two novel compounds (1, 2) and two known ones (5, 6), were isolated by reverse-phase semi-preparative liquid chromatography and identified on the basis of NMR and MS data. Other two degradation products (3, 4) were determined by LC-MS analysis.

Graphical AbstractSlavianolic acid A, a bioactive component isolated from the roots of Salvia miltiorrhiza, is unstable in the thermal condition. The major thermal degradation products were salvianolic acid C (5), isosalvianolic acid C (6), and other four stereo isomers (1–4).Figure optionsDownload full-size imageDownload as PowerPoint slide