| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2539320 | Fitoterapia | 2010 | 5 Pages |
The preventive effects of Gingkoselect (100 mg/kg/day, orally, 21 days) on spatial memory deficits induced by a chronic restraint stress (2 h daily, 21 days) or chronic corticosterone treatment (5 mg/kg, subcutaneously, 21 days) were investigated using the Barnes maze.Chronic corticosterone, but not chronic stress, impaired spatial memory, as shown by increased latency to finding escape tunnel in the maze. Gingkoselect normalized cognitive deficits in rats chronically treated with corticosterone, and improved memory above the control levels in the chronically stressed rats.
Graphical abstractGinkgo biloba extract (Gingkoselect) prevents spatial memory impairment caused by chronic glucocorticoid therapy.Figure optionsDownload full-size imageDownload as PowerPoint slide
