Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2539363 | Fitoterapia | 2009 | 5 Pages |
Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani, with an IC50 value of 45 µg/mL, while GPE presented an IC50 value of 49 µg/mL. Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC50 values of 3.7 µg/mL and 7.0 µg/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC50 values (about 20 µg/mL), while Hautriwaic acid lactone led to an IC50 value of 0.8 µg/mL (D6 clone).
Graphical abstractCompounds 3, 6 and 7 were isolated for the first time from B. dracunculifolia. Ursolic acid (1) and hautriwaic acid lactone (9) showed the highest antileishmanial activities.Figure optionsDownload full-size imageDownload as PowerPoint slide