Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells

A new compound, named quinquefoloside-Lc (1), together with nine known compounds, was isolated from leaves of Panax quinquefolium, and its structure was elucidated as 3β,12β,20S-trihydroxy-25-methoxydammar-23-ene 3-O-β-d-glucopyranosyl (1 → 2) β-d-glucopyranosyl-20-O-β-d-xylopyanosyl (1 → 6) β-d-glucopyranoside (1), on the basis of MS, 1D-and 2D-NMR experiments as well as by chemical degradation. The cytotoxicity of these compounds against human breast cancer MCF-7 cell line was also tested by MTT method.

Graphical abstractA new compound, named Quinquefoloside-Lc (1), together with nine known compounds, was isolated from leaves of Panax quinquefolium, and its structure was elucidated as 3β, 12β, 20S-trihydroxy-25-methoxydammar-23-ene 3-O-β-d-glucopyranosyl (1 → 2)β-d-glucopyranosyl-20-O-β-d-xylopyanosyl(1 → 6)β-d-glucopyranoside (1), on the basis of MS, 1D-and 2D-NMR experiments as well as by chemical degradation. The cytotoxicity of these compounds against human breast cancer MCF-7 cell line was also tested by MTT method. The structure of Quinquefoloside-Lc (1) was shown as follows.Figure optionsDownload full-size imageDownload as PowerPoint slide