| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2539501 | Fitoterapia | 2009 | 6 Pages |
Abstract
The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID50 84.0 (54.8–128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H+,K+-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE.
Graphical abstractInhibition of ethanol-induced gastric lesions and acetic acid-ulcers by hydroalcoholic extract of Salvia officinalis (HE).Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Bárbara Mayer, Cristiane Hatsuko Baggio, Cristina Setim Freitas, Ana Cristina dos Santos, André Twardowschy, Heros Horst, Moacir Geraldo Pizzolatti, Gustavo Amadeu Micke, Melina Heller, Élide Pereira dos Santos, Michel Fleith Otuki,