Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2539575 | Fitoterapia | 2007 | 7 Pages |
Abstract
Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action.
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Authors
Victor Barbastefano, Maira Cola, Anderson Luiz-Ferreira, Elisângela Farias-Silva, Clélia A. Hiruma-Lima, Daniel Rinaldo, Wagner Vilegas, Alba R.M. Souza-Brito,