Article ID Journal Published Year Pages File Type
2539875 Fitoterapia 2006 4 Pages PDF
Abstract

Gigantol (1) and 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2) from the orchid Scaphyglottis livida induced a significant concentration-dependent relaxation of the contractions evoked by noradrenaline (NA) in endothelium-intact and denuded rat aorta rings. Incubation with NG-nitro-l-arginine methyl ester (l-NAME, 1 × 10− 5 M) or methylene blue (MB, 1 × 10− 7 M) significantly reduced the relaxation induced by the stilbenoids 1 and 2. The results suggested that two or more mechanisms are involved in the vasorelaxant effects of both compounds.

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