Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2539942 | Fitoterapia | 2007 | 5 Pages |
Abstract
The methanolic extracts of the barks and pneumatophores of Xylocarpus moluccensis were assessed for their effects on the central nervous system (CNS) using a series of established pharmacological tests including pentobarbitone-induced sleeping time, open field, hole cross, hole-board and evasions tests in mice model. These extracts produced a dose-dependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field, hole cross, head-dip and evasion tests. These results suggest that both the bark and pneumatophore extracts possess CNS depressant activity, the pneumatophore extract being more potent than the bark extract.
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Authors
Satyajit D. Sarker, Shaikh J. Uddin, Jamil A. Shilpi, Razina Rouf, Monzur-E-Mohsina Ferdous, Lutfun Nahar,