Article ID Journal Published Year Pages File Type
2540019 Fitoterapia 2007 4 Pages PDF
Abstract

The essential oil of the Hyptis fruticosa leaves was analyzed by GC/MS and evaluated for antinociceptive property as well as acute toxicity in mice. The essential oil, at doses of 100, 200, and 400 mg/kg (s.c.), produced significant inhibition of acetic acid-induced writhing, but did not manifest a significant effect in hot-plate test. There was no acute toxicity at doses up to 5 g/kg. Bicyclogermacrene, 1,8-cineole, α-pinene, and β-caryophyllene were the major compounds detected in the essential oil.

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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
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