| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2540095 | Fitoterapia | 2006 | 5 Pages |
Abstract
The antiinflammatory activity of the aqueous extract of Polygala japonica (AEPJ) was investigated in mice and rats to find the pharmacological basis for its ethnomedical use. The extract produced a significant inhibition of peritoneal and cutaneous vascular permeability induced by acetic acid and histamine, respectively and ear swelling induced by picryl chloride in mice at the dose of 25.0 mg/kg. Moreover, the extract markedly inhibited footpad edema induced by histamine in rats, and decreased prostaglandin E2 (PGE2) content in carrageenan-induced air-pouch at doses of 12.5 and 6.25 mg/kg respectively.
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Authors
Junping Kou, Minda Si, Guofei Dai, Yuwen Lin, Danni Zhu,