| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2545687 | Journal of Ethnopharmacology | 2010 | 4 Pages |
Ethnopharmacological relevanceExtracts of the medicinal plant species Dodonaea polyandra were investigated as part of a collegial research partnership between Northern Kaanju traditional owners represented by Chuulangun Aboriginal Corporation (centred on the Wenlock and Pascoe Rivers, Cape York Peninsula, Queensland, Australia) and university-based researchers. D. polyandra, known as “Uncha” in Kaanju language, is used in Northern Kaanju Traditional Medicine for relief from pain associated with toothache and related ailments. The species has a restricted distribution in Cape York Peninsula and there has been no previous Western scientific investigation of its pharmacology or chemistry.Aim of the studyThe current study investigates the anti-inflammatory effects of several extracts from D. polyandra.Materials and methodsPhytochemical screening was conducted using TLC. Anti-inflammatory effects of leaf extracts were determined using an acute mouse ear oedema model induced by croton oil and 12-o-tetradecanoylphorbol-13-acetate (TPA) chemical irritants.ResultsFlavonoid and terpenoid secondary compounds were detected in leaf extracts of D. polyandra. Non-polar hexane and methylene chloride/methanol extracts showed potent inhibition of inflammation in TPA-induced mouse ear oedema by 72.12 and 79.81%, respectively, after 24 h at 0.4 mg/ear.ConclusionIn a mouse model of acute inflammation, this study revealed that leaf extracts of D. polyandra possess significant anti-inflammatory potential. These results contribute to a Western scientific understanding of the ethnopharmacological use of the plant in Northern Kaanju Medicine for reducing tooth-related pain.
Graphical abstractLeaf extracts of Dodonaea polyandra possess significant anti-inflammatory activity in a mouse ear oedema model of acute inflammation. This contributes to a Western scientific understanding of the use of the plant in the traditional medicine of the Northern Kaanju people, Cape York Peninsula, Australia.Figure optionsDownload full-size imageDownload as PowerPoint slide
