Anti-inflammatory and analgesic properties of Drynaria quercifolia (L.) J. Smith

Ethnopharmacological relevanceDrynaria quercifolia (L.) J. Smith (Polypodiaceae), has been widely used by ethnic groups of India to treat inflammation, rheumatism, headache, bone fracture, jaundice, etc.Aim of the studyTo evaluate the anti-inflammatory and analgesic properties of the ethanolic extract of rhizome of Drynaria quercifolia (DQ) and its phytochemical profile.Materials and methodsDQ was used to evaluate the anti-inflammatory and analgesic effects using carrageenan-induced paw oedema/cotton pellet-induced granuloma in Wistar rats and acetic acid-induced writhing/formalin-induced paw licking test in Swiss albino mice respectively.ResultsOral administration of DQ produced significant inhibition of carrageenan-induced paw oedema and granuloma formation in rats, almost comparable to that caused by indomethacin. DQ significantly attenuated acute and delayed phases of formalin-induced pain and acetic acid-induced writhing episodes in mice. The analgesia was comparable to that produced by sodium salicylate and aspirin respectively. Phytochemical analysis gave positive tests for catechin, coumarins, flavonoids, phenolics, saponin, steroids, tannins, and triterpenes. The total phenolics in DQ was 244 mg/g and naringin content was 0.048%.ConclusionThe results suggest the presence of potent anti-inflammatory and analgesic principles in DQ that justifies its use for alleviating painful inflammatory conditions.

Graphical abstractDrynaria quercifolia (L.) J. Smith (Polypodiaceae) rhizomes, used by tribals South India against inflammation and pain was evaluated for its anti-inflammatory and analgesic activities in vivo. The ethanolic extract, DQ produced significant inhibition of inflammation and pain.Figure optionsDownload full-size imageDownload as PowerPoint slide