Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching

Aim of the studyThe study was aimed to investigate the ethanol extract of Arachniodes exilis for the antioxidant and hepatoprotective activity.Materials and methodsAntioxidant activity was evaluated by different assays, including reducing power, lipid peroxidation, 2, 2′-diphenyl-1-picrylhydrazyl (DPPH), 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), superoxide anion, hydroxyl radicals and hydrogen peroxide. The hepatoprotective activity of ethanol extract was studied on mice liver damage induced by CCL4 by monitoring biochemical parameters.ResultsThe extract showed potent activities on reducing power, lipid peroxide, DPPH, ABTS, superoxide anion, hydroxyl radical and hydrogen peroxide. And oral administration of Arachniodes exilis at different doses resulted in significant improvement on the levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, malondialchehyche and superoxidedismutase.ConclusionThe results indicate that this plant possesses potential antioxidant and hepatoprotective properties and has therapeutic potential for the treatment of liver diseases.

Graphical abstractIn the hepatoprotective activity assay, the Levels of GPT and GOT were significantly reduced in groups treated with ethanol extract of Arachniodes exilis (EE). (1: Normal; 2: CCl4 control; 3: Silymarin; 4 – 5: EE 360, 720 mg/kg.).Figure optionsDownload full-size imageDownload as PowerPoint slide