Anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata DC flower

Ethnopharmacological relevanceKigelia pinnata DC is extensively used in Indian traditional medicine for several diseases including inflammatory and painful disorders.Aim of the studyThe aim of the present study is to investigate the possible anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata flower (MKFL) to support the medicinal uses claimed by folklore practitioners.Materials and methodsMKFL is evaluated for its anti-inflammatory activity in carrageenan-induced paw edema model in rats and analgesic activity in acetic acid-induced writhing, hot plate and formalin-induced paw licking models in mice.ResultsMKFL exhibited a significant (P < 0.01) anti-inflammatory and analgesic activities with the doses of 100, 200 and 400 mg/kg b.w. in rats and mice respectively.ConclusionsThe results of the experimental study thus strongly support the traditional use of this plant for inflammatory and pain disorders.

Graphical abstractThe methanolic extract of Kigelia pinnata DC flower exhibited anti-inflammatory and analgesic activities. The present study confirms the claimed utilization of the plant against pain and inflammatory complaints in Indian folklore medicine.Figure optionsDownload full-size imageDownload as PowerPoint slide