Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
25465 | Journal of Biotechnology | 2007 | 11 Pages |
Abstract
We study equilibrium aspects of molecular recognition of two biomolecules using idealized model systems and methods from statistical physics. Starting from the basic experimental findings we demonstrate exemplarily how an idealized coarse-grained model for the investigation of molecular recognition of two biomolecules can be developed. In addition we provide details regarding two model systems for the recognition of a flexible and a rigid biomolecule respectively, the latter taking into account conformational changes. We focus particularly on the interplay and influence of the correlations of the residue distributions of the biomolecules on the recognition process.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Hans Behringer, Thorsten Bogner, Alexey Polotsky, Andreas Degenhard, Friederike Schmid,