Article ID Journal Published Year Pages File Type
2546715 Journal of Ethnopharmacology 2009 7 Pages PDF
Abstract

Aim of the studyRadix Bupleuri, is one of the most frequently prescribed crude herbs in the prescriptions of traditional Chinese medicine for the treatment of inflammatory diseases and auto-immune diseases. This study was to determine whether the crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var. parvifolium, had beneficial effects on autoimmune disease.Materials and methodsBALB/c mice were immunized with CJ-S131 in Freund's complete adjuvant on day 0, and then boosted on day 14. BPs 15 or 30 mg kg−1 day−1, or prednisone 5 mg kg−1 day−1 was given to BALB/c mice intragastrically from day 0 to day 34.ResultsTreatment with BPs 15 or 30 mg kg−1 day−1 for 35 days protected kidney from glomerular injury with reduced immunoglobulin deposition and lowered proteinuria. The increased production of serum autoantibodies and total immunoglobulin G (IgG) was also inhibited. BPs 30 mg kg−1 day−1 improved weight loss and spleen swelling when compared with vehicle-treated group.ConclusionsThese findings suggested that Bupleurum polysaccharides had a beneficial effect on systemic lupus erythematosus-like syndroma induced by CJ-S131 in BALB/c mice.

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