Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2547790 | Journal of Ethnopharmacology | 2007 | 5 Pages |
Abstract
We investigated the effects of echinacoside, a phenylethanoid glycoside isolated and purified from the stems of Cistanche salsa, a Chinese herbal medicine, on the striatal extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in 6-hydroxydopamine (6-OHDA) lesion rats. Seven days after 6-OHDA was injected into the right striatum of rats, the striatal extracellular levels of DA, DOPAC and HVA fell significantly (PÂ <Â 0.01 vs. vehicle), as demonstrated by the method of cerebral microdialysis and high performance liquid chromatography with electrochemical detection. However, simultaneous treatment with echinacoside (7.0, 3.5Â mg/kg) attenuated the diminution of them (PÂ <Â 0.01 vs. model). The results implied that echinacoside could protect the striatal dopaminergic neurons from injury induced by 6-OHDA and may be useful in the prevention and treatment of Parkinson's disease (PD).
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Authors
Hong Chen, Fu Chun Jing, Chang Ling Li, Peng Fei Tu, Qiu Sheng Zheng, Zheng Hua Wang,