Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2548659 | Journal of Pharmacological Sciences | 2016 | 4 Pages |
Abstract
We examined the effect of chondroitin sulfate (CS), a compound used in the treatment of osteoarthritis and joint pain, on the formalin-induced tactile allodynia in mice. A repeated oral administration of CS (300 mg/kg, b.i.d.) significantly ameliorated the formalin-induced tactile allodynia from day 10 after formalin injection. On day 14, the phosphorylation of spinal p38 MAPK and subsequent increase in c-Fos-immunoreactive dorsal lumbar neurons were attenuated by the repeated administration of CS. These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord.
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Authors
Wataru Nemoto, Kotaro Yamada, Yoshiki Ogata, Osamu Nakagawasai, Katsuhito Onodera, Hidetomo Sakurai, Koichi Tan-No,