| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2549753 | Journal of Pharmacological and Toxicological Methods | 2010 | 13 Pages |
Abstract
The effects of dofetilide were comparable in the two models for delayed repolarization but the isolated heart appears to be a better predictor for arrhythmias and a unique in vitro model to assess arrhythmogenic potential of QT prolonging compounds at least when associated with IKr/hERG inhibition.
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Authors
Michel Roche, Céline Renauleaud, Véronique Ballet, Michel Doubovetzky, Jean-Michel Guillon,