| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2549881 | Journal of Pharmacological and Toxicological Methods | 2007 | 9 Pages |
Abstract
Compared to control rats, deprived rats showed a significant and selective anticonflict effect of desipramine on the stressful and complex operant performance. The animal model of perinatally protein-deprived rats along with the Geller-Seifter's operant behavioral paradigm may represent a more sensitive approach to model human anxiety sensitive to antidepressant treatments by considering the combined impact of both early biological trauma and adult learned experiences under the same design.
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Authors
Nora Silvana Vigliecca, Silvia Cristina Molina, Marisa Carola Peñalva,