| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2550124 | Journal of Pharmacological and Toxicological Methods | 2009 | 11 Pages |
Abstract
IKs inhibition appears to be more likely to produce TdP in isolated guinea pig hearts than IKr inhibition. Chromanol 293B did not produce TdP in rabbit hearts presumably due to a low level of IKs channels in the heart. TdP produced in this study was consistent with the notion that its production was a consequence of reduced repolarization reserve, thereby causing rhythmic abnormalities. This isolated, perfused, and spontaneously beating rabbit and guinea pig heart preparation in hypokalemic medium may be useful as a preclinical test model for studying proarrhythmic liability of compounds in new drug development.
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Authors
Hsien C. Cheng, Josephine Incardona,