| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2550359 | Journal of Pharmacological and Toxicological Methods | 2006 | 8 Pages |
Abstract
We have demonstrated that this noninvasive method of CO quantitation reliably estimates heme degradation with sensitivity to distinguish between different types of HO-manipulating xenobiotics in a dose-dependant manner in both mouse and rat models. Furthermore, VeCO measurements allow nearly real-time determinations of CO and bilirubin formation, which helps to illustrate the time course of drug action.
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Authors
Ryan A. Dercho, Kanji Nakatsu, Ronald J. Wong, David K. Stevenson, Hendrik J. Vreman,