Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2561598 | Pharmacological Research | 2006 | 6 Pages |
Abstract
The binding of BmK IT2 to insect and mammal sodium channels was investigated by surface plasmon resonance technique. The results showed that BmK IT2 could bind not only to cockroach neuronal membranes but also to rat cerebrocortical and hippocampal synaptosomes with distinct affinity. The binding of BmK IT2 could be competed significantly by BmK AS and BmK abT, but not by AaH II, BmK I and veratridine. Furthermore, BmK αIV could partially inhibit the binding of BmK IT2 to rat cerebrocortical synaptosomes and cockroach neuronal membranes, but not to rat hippocampal synaptosomes. These results suggested that BmK IT2 had diverse binding properties on the mammal and insect sodium channels.
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Authors
Zhi-Fang Chai, Zhan-Tao Bai, Tong Liu, Xue-Yan Pang, Yong-Hua Ji,