Article ID Journal Published Year Pages File Type
2562519 Pharmacological Research 2006 8 Pages PDF
Abstract

The HDAC inhibitor Trichostatin A (TSA) exhibits antitumour activity in various tumour cells. However, little is known about the effect of TSA on growth of human tongue carcinoma cells. In this study, we observed that TSA concentration-dependently inhibited growth of human tongue carcinoma Tca8113 cells by inducing G2/M arrest, apoptosis, up-regulation of the pro-apoptotic protein Bax and down-regulation of the anti-apoptotic proteins Bcl-2 and Bcl-XL which are regulated by the transcription factor nuclear factor (NF)-κB. Coincident with this observation, TSA induced a concentration-dependent reduction of constitutive and tumour necrosis factor (TNF)-α-induced NF-κB activation in Tca8113 cells. This induction was correlated with decreased phosphorylation and increased expression of inhibitors of NF-κB (IκB)α induced by TSA. Overall, our results indicate inhibition of NF-κB activation contributes, at least partially, to the antitumour activity of TSA in human tongue carcinoma cells.

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