Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2563508 | Pharmacology & Therapeutics | 2012 | 11 Pages |
Abstract
Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical variation seen in response to pharmacotherapeutic drugs. This affects the likelihood of experiencing adverse drug reactions and also of achieving therapeutic success. In this paper, we review key studies in cardiovascular pharmacogenetics that reveal genetic variations underlying the outcomes of drug treatment in cardiovascular disease. Examples of genetic associations with drug efficacy and toxicity are described, including the roles of genetic variability in pharmacokinetics (e.g. drug metabolizing enzymes) and pharmacodynamics (e.g. drug targets). These findings have functional implications that could lead to the development of genetic tests aimed at minimizing drug toxicity and optimizing drug efficacy in cardiovascular medicine.
Keywords
FDAABCB1LVEFPGPCHDLDL-CVKORC1NOSACEDCMCyPUGTP-glycoproteincytochrome p450 enzymeMyocardial infarctionAngiotensin-converting enzymeApoeapolipoprotein EU.S. Food and Drug Administrationcoronary heart diseasePersonalized therapyPharmacodynamicsPharmacogeneticsPharmacokineticsAtrial fibrillationlow density lipoproteinLDLGenome-wide association studyGWASheart failurenitric oxide synthaseFamilial hypercholesterolemiaPolymorphismsSingle nucleotide polymorphismSNPDilated cardiomyopathyleft ventricular ejection fractionlow density lipoprotein cholesteroladrenergic receptor
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Authors
Renier Myburgh, Warren E. Hochfeld, Tyren M. Dodgen, James Ker, Michael S. Pepper,