| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2563865 | Pharmacology & Therapeutics | 2008 | 11 Pages |
Abstract
The dog model with chronic, complete atrio-ventricular block has been used frequently for proarrhythmic drug screening. The ventricular remodeling seen after ablation of the AV node enhances the susceptibility for repolarization-dependent arrhythmias. In this review, we 1) describe the cellular and molecular basis of ventricular remodeling, 2) validate the CAVB dog as a drug screening model and 3) introduce a new surrogate predictive proarrhythmic parameter: beat-to-beat variability of repolarization.
Keywords
PVTAcquired long-QT syndromeHW/BWMAPDMonophasic action potential durationCAVBearly after depolarizationdelayed after depolarizationTorsades de pointesBVREADSEBTDPLQTSDADSTVSCDMEBAtrio-ventricularECGelectrocardiogramERPright ventricleleft ventricleBeat-to-beat variability of repolarizationShort-term variabilitySinus rhythmLong-QT syndromeVentricular fibrillationSudden cardiac deathmapMonophasic action potential
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Authors
Avram Oros, Jet D.M. Beekman, Marc A. Vos,