Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2564018 | Pharmacology & Therapeutics | 2013 | 11 Pages |
Abstract
Plasmacytoid dendritic cells (pDCs) represent a unique subset of dendritic cells that play distinct and critical roles in the immune response. Importantly, pDCs play a pivotal role in several chronic autoimmune diseases strongly characterized by an increased risk of vascular pathology. Clinical studies have shown that pDCs are detectable in atherosclerotic plaques and others have suggested an association between reduced numbers of circulating pDCs and cardiovascular events. Although the causal relationship between pDCs and atherosclerosis is still uncertain, recent results from mouse models are starting to define the specific role(s) of pDCs in the disease process. In this review, we will discuss the role of pDCs in innate and adaptive immunity, the emerging evidence demonstrating the contribution of pDCs to vascular pathology and we will consider the possible impact of pDCs on the acceleration of atherosclerosis in chronic inflammatory autoimmune diseases. Finally, we will discuss how pDCs could be targeted for therapeutic utility.
Keywords
BST-2HFDLDLRAPCtDCSODNEPCsIDOACPAT1DIRFMHC-IILNsVSMCsBDCAOx-LDLCACSOligonucleotidesLAG-3TNFHEVsNODMDPsAmIcDCsECsNETspDCsAtherosclerosisRheumatoid arthritisanti-citrullinated protein antibodiesBlood dendritic cell antigenAntigen presenting cellsApoeApolipoprotein-EinterferonIFNinterferonsindoleamine 2,3-dioxygenasecoronary artery diseaseCardiovascular diseasesneutrophil extracellular trapsdiphtheria toxinautoimmunityType 1 diabetesNon-obese diabeticCVDHigh fat dietconventional dendritic cellsVascular smooth muscle cellsendothelial precursor cellsEndothelial cellsplasmacytoid dendritic cellsAcute myocardial infarctionCADinterferon regulatory factorrheumatoid factorgranulocyte colony-stimulating factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)G-CSFtumor necrosis factorTRAILSystemic lupus erythematosusSLEoxidized low density lipoproteintumor necrosis factor-related apoptosis-inducing ligandwild typehigh endothelial venulesMajor histocompatibility complex class IIcirculating angiogenic cellslymph nodeslow density lipoprotein receptor
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Authors
Gianluca Grassia, Neil MacRitchie, Andrew M. Platt, James M. Brewer, Paul Garside, Pasquale Maffia,