Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2579357 | Thérapie | 2009 | 6 Pages |
Abstract
A 33-year-old man was hospitalized unconscious on suspicion of acute diazepam and hexobarbital intoxication, a barbiturate not marketed in France. Its quantification was developed by gas chromatography coupled with mass spectrometry detection and validated on onehundred μL of plasma extracted by a liquid/liquid method. Hexobarbital and diazepam concentrations in initial plasma samples were at toxic levels, respectively 15 900 ng/mL and 13 800 ng/mL. Hexobarbital toxicokinetic was studied during 175 h and analysed with a non-compartimental model. Half-life value of 61,8 h was found, being much longer than already published hexobarbital half-lives (between 3.2 h and 6.9 h). The reasons of this long half-life were discussed according to metabolism and pharmacogenetic.
Keywords
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Authors
Emmanuelle Guillot, Emuri Abe, Ãmilie Gautier, Djillali Annane, Jean-Claude Alvarez,