Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2638965 | American Journal of Infection Control | 2008 | 4 Pages |
Abstract
We examined the impact of an antimicrobial formulary change, based on reduction in third-generation cephalosporin use, on resistant gram-negative pathogens in a tertiary hospital. No significant changes were demonstrated in their incidence per 1000 patient-days. Otherwise, there was a significant decrease in rate of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (63.1% to 52.5%, P = .04) and third-generation cephalosporin-resistant Enterobacter species (31.4% to 25%, P = .04) between the 2 study periods. On the other hand, there was also a significant increase in rate of ampicillin-sulbactam-resistant Acinetobacter baumannii (8% to 47%, P = .01) after the implementation of the formulary intervention.
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Authors
Guilherme H.C. Furtado, Luciana B. Perdiz, Iolanda Lopes Santana, Márcia M.S.C.R. Camargo, Fernanda C. Parreira, Daniela B. Angelieri, Eduardo A.S. Medeiros,