| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 26618 | Journal of Photochemistry and Photobiology A: Chemistry | 2014 | 7 Pages |
•Two-photon (TP) active 4-dimethylaminocinnamoyl coumarins were synthesized.•Strong TPF was observed for each of the compounds.•These coumarins exhibited considerable Stokes shifts and moderate fluorescence quantum efficiencies.•These coumarins have the potential to be used in the development of a biological imaging probe.
A series of two-photon (TP) active 4-dimethylaminocinnamoyl coumarins were synthesized. These compounds exhibit red shift in absorption and considerable Stokes shift in emission spectra in comparison to the parent coumarin. Large TP absorption cross-sections were measured for all the coumarins in dilute solutions. A correlation between the chemical structure and TP characteristics was established. TP confocal microscopy revealed that these coumarin derivatives can be internalized by cancer cells rendering them a potential candidate as a label in TP confocal imaging.
Graphical abstractA series of two-photon (TP) active 4-dimethylaminocinnamoyl coumarins were synthesized that exhibit considerable Stokes shift in emission and can be internalized by cancer cells rendering them a potential candidate as a label in TP confocal imaging.Figure optionsDownload full-size imageDownload as PowerPoint slide
