Article ID Journal Published Year Pages File Type
27123 Journal of Photochemistry and Photobiology A: Chemistry 2012 6 Pages PDF
Abstract

The photochemical behaviour of rivastigmine has been investigated under UV-B irradiation by HPLC and NMR. Kinetic data have been obtained irradiating aqueous solutions (5 × 10−5 M). For mechanistic purposes and products studies irradiation has also been carried out on concentrated solutions (1 × 10−3 M) in water/acetonitrile, acetonitrile, methanol, methanol/acetonitrile, in the presence and absence of oxygen. Photoproducts, isolated by chromatographic processes, have been identified by spectroscopic means. Photochemical cleavage of the benzyl-nitrogen bond occurs and leads to radical-derived and, mainly, ion-derived products. Mechanistic pathways have been hypothesised on the basis of both steady-state irradiation and laser flash photolysis experiments.

► By UV-B radical and/or ionic cleavage of the benzyl amine group of the drug occurs. ► Mechanistic routes are based on steady-state and laser flash photolysis experiments. ► Water as solvent plays a determinant role in favouring electron-transfer reactions. ► The main photoproduct, an aryl ketone, is a photosensitizer.

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Physical Sciences and Engineering Chemical Engineering Bioengineering
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