| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2775539 | Experimental and Molecular Pathology | 2011 | 6 Pages |
Abstract
⺠We investigated the influence of anthracosis and p16ink4a gene aberrant methylation on small-sized adenocarcinoma. ⺠The mean Anthracotic index(AI) and the frequency of p16ink4a gene aberrant methylation of heavy smokers were significantly higher than nonsmokers. ⺠The frequency of p16ink4a gene aberrant methylation of early stage small-sized adenocarcinoma was lower than advanced and poorly stage. ⺠p16ink4a protein expression level of early stage small-sized adenocarcinoma was significantly higher than poorly stage. ⺠AI and p16ink4a gene aberrant methylation may provide a potential universal biomarker for small-sized adenocarcinoma.
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Authors
Daye Wang, Jue Wang, Yong Li, Zhili He, Yong Zhang,