| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 28235 | Journal of Photochemistry and Photobiology A: Chemistry | 2007 | 6 Pages |
Abstract
Irradiation of rosuvastatin in water by sunlight or UV lamp (Pyrex) affords cyclic compounds. The main photo-induced reaction is cyclization of the drug to give diastereomeric dihydrobenzoquinazolines. Products derived from side-chain loss were also isolated in the irradiation mixture, and characterized as dihydrobenzoquinazoline and benzoquinazoline derivatives by spectroscopic means. Photoproducts structure elucidation and mechanistic hypothesis are reported.
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Authors
Anna Astarita, Marina DellaGreca, Maria Rosaria Iesce, Sara Montanaro, Lucio Previtera, Fabio Temussi,