| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2862849 | American Journal of Hypertension | 2006 | 8 Pages |
Abstract
The findings demonstrate a strong and significant association of the Gly16 and Glu27 alleles with obesity. Lower slopes between leptin and NE in the subjects carrying these β2-adrenoceptor polymorphisms indirectly indicate a blunted leptin-mediated sympathetic nerve activity. We propose that the β2-adrenoceptor polymorphisms related to blunted leptin-mediated sympathetic activation offers further proof for the mechanisms of obesity.
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Authors
Kazuko Masuo, Tomohiro Katsuya, Hideki Kawaguchi, Yuxiao Fu, Hiromi Rakugi, Toshio Ogihara, Michael L. Tuck,