| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2862893 | American Journal of Hypertension | 2006 | 10 Pages |
Abstract
These results demonstrate that an infusion of ang II induced the expression of VEGF mainly through AT1 receptors, and increased the expression of VEGF receptors, tie-2, and Ang1/Ang2 ratio mainly through AT2 receptors. The increase of VEGF/flk-1/flt-1 may be associated with vascular permeability, monocyte/macrophage infiltration, and rarefaction of peritubular capillaries, and the increase of the Ang1/Ang2 ratio may be a compensatory mechanism counteracting the permeability inducing effect of VEGF after ang II infusion.
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Authors
Hiroyuki Kitayama, Yohei Maeshima, Yuki Takazawa, Yoshihiko Yamamoto, Yan Wu, Kunihiro Ichinose, Kumiko Hirokoshi, Hitoshi Sugiyama, Yasushi Yamasaki, Hirofumi Makino,