Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2862942 | American Journal of Hypertension | 2006 | 8 Pages |
Abstract
The AR + HT rats had the most severe myocardial abnormalities. High dose captopril was effective to slow LVH and preserve normal LV ejection fraction in isolated HT or AR, but was less effective when both pathologies were combined. Prohypertrophic stimuli clearly remain active in HT + AR despite ACE inhibition. These results suggest that a very aggressive medical treatment strategy may be required to optimize LV protection when AR and HT co-exist.
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Authors
Jacques Couet, Martin Gaudreau, Dominic Lachance, Eric Plante, Elise Roussel, Marie-Claude Drolet, Marie Arsenault,