Article ID Journal Published Year Pages File Type
28997 Journal of Photochemistry and Photobiology A: Chemistry 2008 5 Pages PDF
Abstract

The wide range of physical and chemical properties of modified fullerenes has drawn increasing attention in the past few years. As part of this research, this paper describes the preparation, characterization, and photophysical properties of a new fullerene derivative chemically modified with a tetrazole. The photophysical properties were studied by EPR radical spin-trapping technique and showed that reactive oxygen species (ROS) can be produced through UVA photosensitization. EPR spin-trapping experiments with singlet oxygen (1O2) and superoxide (O2−) inhibitors (β-carotene and superoxide dismutase, respectively) revealed also that: (i) the main ROS produced is 1O2 and (ii) 1O2 is being partially dismutated to O2−. The results suggest that this derivative can be used in biological applications, as for example, in topic photodynamic therapy (PDT) as a photosensitizer.

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Physical Sciences and Engineering Chemical Engineering Bioengineering
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